Three Significant Research Findings: Advancing Psoriasis Treatments
Being a patient advocate for psoriasis and psoriatic arthritis has opened my eyes to many things. We are more aware of scientific developments around the research of our disease.
You can't turn on the TV without hearing about a drug for psoriasis. I'm no science junkie but when it concerns my health and the people for whom I am supporting, everything matters.
Researching advancing psoriasis treatments
I have spoken to a few psoriasis warriors and ask them about their experiences receiving medical treatment. You will find that there is never a one size fits all solution. Psoriasis presents itself in many forms on our bodies. So prescribing targeted treatments are often difficult.
Yet, advancements in clinical experiments over the past few years have shed a light of hope in the journey towards finding a cure.
An effective treatment: managing glucose
We understand psoriasis to be the occurrence of overgrowth of skin cells. Glucose is needed by our bodies for the natural processes of cell division and growth. Scientists from UT Southwestern Medical Center have attempted to slow down this growth by inactivating the glut. This is the protein that is responsible for transporting glucose to cell membranes for their growth.
Completed in 2018, this study experimented on mice with both a drug-based inhibitor as well as a topical solution. It produced successful results; a reduction in skin overgrowth that did not adversely affect its development. This has since paved the way for further studies. Great news for us.
Psoriasis and treating the immune system
It has been long-held knowledge that our immunities respond to harmful substances in our bodies by inducing inflammation. Yet, inflammatory cells have been found by scientists to produce a compound called itaconate which reduces inflammation instead of heightening it.
This study, conducted at Washington University School of Medicine, is significant for its findings. Think of our bodies as a system of highways, certain routes lead to specific destinations. In the case of psoriasis, the IL-17 pathway in our bodies is the primary path leading to the onset of autoimmune diseases. I believe they could be on to something here.
Itaconate decreases 1 key protein that has been linked to psoriasis and this discovery.
Molecular level treatments
2020 has been full of so many surprises. If you need one reason to see why this year should not be written off, this is it. Wyss Institute has found an effective means of delivering molecular level treatments. They are doing this without the use of needles or other invasive methods. For a long time, scientists have had to work around the barrier which surrounds our skin.
However, as recent as July 2020, a salt in liquid form has presented itself as a promising partner to siRNAs. These are molecules that destroy targeted genes in cells. The results of the experiment revealed decreased thickening of the epidermis as well as redness and scaling. There was also a reduction in the overgrowth of keratin.
The future is bright
While the end game of psoriatic disease research is ultimately to find a cure, along the way researchers inevitably uncover ways to improve the lives of those with psoriasis and psoriatic arthritis.
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