Wynzora (calcipotriene and betamethasone dipropionate)

Reviewed by: HU Medical Review Board | Last reviewed: September 2023 | Last updated: September 2023

Wynzora® (calcipotriene and betamethasone dipropionate) is a prescription topical cream used to treat plaque psoriasis in people 18 and older. Wynzora is a novel skin cream applied to affected areas once a day for up to 8 weeks.1,2

Wynzora uses PAD Technology™, a process that allows oil and water to be mixed into a cream using smaller amounts of surfactants. Surfactants are chemicals that work to combine materials that otherwise would not mix. This process improves the cream’s absorption, spreadability, and convenience.2

What are the ingredients in Wynzora?

The active ingredients in Wynzora are betamethasone dipropionate and calcipotriene.1

How does Wynzora work?

The active ingredients work together to treat plaque psoriasis:1

  • Betamethasone is a steroid that relieves skin problems like itching, pain, redness, and swelling
  • Calcipotriene is a form of vitamin D that slows down the production of skin cells in areas affected by psoriasis

What are the possible side effects?

The most common side effects of Wynzora include:1

  • Headache
  • Irritation in areas where there cream has been applied
  • Upper respiratory infection

These are not all the possible side effects of Wynzora. Talk to your doctor about what to expect when taking Wynzora. You also should call your doctor if you have any changes that concern you when taking Wynzora.

Other things to know

Before starting treatment with Wynzora, tell your doctor if you have:1

  • A calcium metabolism disorder
  • Thinning skin (atrophy) at the treatment site

Avoid getting Wynzora near or in your mouth, eyes, or vagina. Do not apply Wynzora on your face, groin, or armpits. You should not apply Wynzora if you have thinning of your skin (atrophy) at the treatment site.1

There is not enough data to know if Wynzora is safe to use while pregnant or breastfeeding. Before using this drug, tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. They can help you decide if Wynzora is right for you.1

If you are using other products containing calcipotriene or a corticosteroid drug, talk to your doctor before taking Wynzora. Tell your doctor about any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.1,2

For more information, read the full prescribing information of Wynzora.

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