What Is Wynzora® Cream (calcipotriene and betamethasone dipropionate)?
Wynzora® Cream (calcipotriene and betamethasone dipropionate) has been approved by the U.S. Food and Drug Administration (FDA) for treatment of plaque psoriasis in people 18 and older. Wynzora is a novel skin cream applied to affected areas once a day for up to 8 weeks.1,2
Wynzora uses PAD Technology™, a process that allows oil and water to be mixed into a cream using smaller amounts of surfactants. Surfactants are chemicals that work to combine materials that otherwise would not mix. This process improves the cream’s absorption, spreadability, and convenience.1
What are the ingredients in Wynzora?
The active ingredients in Wynzora include:1,2
- Betamethasone dipropionate
How does Wynzora work?
The active ingredients in Wynzora work together to treat plaque psoriasis. Betamethasone is a steroid that relieves skin problems including:3
Calcipotriene is a form of vitamin D. It slows down the production of skin cells in areas affected by plaque psoriasis.3
Wynzora in clinical trials
Wynzora was approved based on the results of a Phase 3 clinical trial. The trial compared Wynzora to another topical cream with the same active ingredients. Nearly 800 people with plaque psoriasis participated. Overall, compared to the other topical cream, Wynzora improved plaque healing and reduced itching.1,2
What are the possible side effects of Wynzora?
The most common side effects of Wynzora include:1,2
- Irritation in areas where there cream has been applied
- Upper respiratory infection
Other less common side effects include:1,2
- Adrenal gland problems
- Cushing’s syndrome, a condition where the body makes too much of the hormone cortisol
- High blood sugar and sugar in the urine
- Too much calcium in the blood or urine
- Vision problems, including an increased risk of cataracts and glaucoma
These are not all the possible side effects of Wynzora. Talk to your doctor about what to expect or if you experience any changes that worry you.
Things to know about Wynzora
Wynzora should be applied to affected areas 1 time per day for up to 8 weeks. Do not apply more than 100 grams per week. Treatment should be stopped when your plaque psoriasis is under control, unless your doctor gives you different instructions.1,2
Avoid getting Wynzora near or in your mouth, eyes, or vagina. Do not apply Wynzora on your face, groin, or armpits. You should not apply Wynzora if you have thinning of your skin (atrophy) at the treatment site.1,2
It is not known if Wynzora is safe and effective for children.1,2
There is not enough information about Wynzora and pregnancy to know if this drug is safe to use when pregnant. The risk for birth defects and miscarriage is not known. Prior to using this drug, tell your doctor if you are pregnant or plan to become pregnant.4
It is not known whether this drug is safe to take while breastfeeding. To minimize potential exposure to their infant, women who are breastfeeding should use Wynzora on the smallest area of skin and for the shortest period of time possible. Women who are breastfeeding should not apply Wynzora directly to the nipple and/or areola.4
If you are using other products containing calcipotriene or a corticosteroid drug, talk to your doctor before taking Wynzora. Tell your doctor about any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.1,2
For more information, read the full prescribing information of Wynzora.