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I went to the Dermatologists, prescribed Apremilast

Hi All

Just back from the Dermatologist and was prescribed Apremilast.

It inhibits the activity of phosphodiesterase type-4 (PDE4) which results in suppression of pro-inflammatory mediator synthesis

Whilst there, I gave my normal history of treatments, explaining that the improvements I have had were mainly from changes in my diet. I was somewhat dismayed when the doctor said there is "No scientific study to prove that diet has positive impact on psoriasis"!!? Which I could have provided multiple scientific studies to the contrary, however I did not want to get into an disagreement as he wanted to try a different drug called Apremilast.

Has anyone used this drug and if so what were the results?

Thanks in advanced.

  1. Hi !

    Thank you for reaching out. Whilst you wait for responses here, I wanted to share a couple of Stories from community members who have tried apremilast (brand name: Otezla):
    I hope that the apremilast will bring you some relief. Please keep us updated on how you get on with it if you can.

    If you don't mind sharing, I also wanted to ask - which dietary changes have you found most helpful? -Catherine, Community Moderator

    1. For dietary changes, the key things I avoid that can improve my skin are:
      Any added sugars just avoid all!
      Beer or lager, any alcohol as we know is not good, but red wine is not too bad 😀
      All dairy, especially milk, cheese etc, made a big difference
      Avoid night shades

      Increased items:
      Drink lots of water
      Vitamin D
      Eat as fresh as you can, eat real food !

    2. , thanks so much for taking the time to share. Quite a few people have mentioned that avoiding these foods helps them manage their psoriasis. I keep meaning to pay more attention to my skin when I'm consuming nightshades, to see if there's any effect... Glad to hear that the red wine isn't too bad!! 😁 -Catherine, Community Moderator

  2. hi fellow amazing psoriasis friends.

    I have just started taking Otezla (Apremilast) which was recommended by the dermatologist for a week now and oh boy I am seeing some changes already !

    However, I do have to admit that by accident I am taking a stronger doze straight away, as I was supposed to be on something called a starter pack, that slowly increased the dose each day so you do not suffer at first with the potential side affects like nausea, headaches etc, When I picked up my prescription from the chemist I was given 30mg tablets instead which I have been taking twice daily so 60mg. I did feel a little tired but after a week don't seem to notice it and my stomach is fine.
    I also take Methotrexate for my joints with no stomach issue.

    Summary, is that my skin feels flatter and much less scaly, the redness is disappearing and this is all just in one week of taking Otezla (Apremilast). Quite excited for the first time in 20 years !!!!

    1. Hi @A1EK, I am glad you also responded to your original comment with your improvement. We are so glad you are feeling better and in such a short period of time. Thank you so much for the follow up. Jill, Team Member

    2. , that is exciting!! I am so pleased to read that you're already seeing improvements already. Hopefully everything will continue to move in the right direction going forward. Please keep us posted if you can! -Catherine, Community Moderator

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