I am on my second biologic medication. The first one gave me some dramatic (to me, anyways) improvement in my condition, but the progress halted, so my derm put me on a new one. This current one has lasted me about a year now, but patches are making a big comeback on my legs and this week my scalp exploded with weeping patches. For those of you who have failed treatments--when did you finally get to the point of knowing it was time to move on?